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Yayoi Murakami, Masafumi Ito, Ikuroh Ohsawa
Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis
www.plosone.org
www.plosone.org
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10 0 0 10 200.0125 412.2141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Human)Tj
3.3165 0 Td
(neuroblastoma)Tj
6.2021 0 Td
(SH-SY5Y)Tj
4.0309 0 Td
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(CRL-2266\))Tj
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(eagle)Tj
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(of)Tj
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(14)Tj
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-10.4654 -1.3039 Td
(H)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 219.685 345.5433 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 223.2566 347.1874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
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(-mixed)Tj
3.0727 0 Td
(gas)Tj
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(10%)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 365.7259 345.5433 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 369.2976 347.1874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4422 0 Td
(5%)Tj
1.457 0 Td
(CO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 402.3496 345.5433 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 405.9212 347.1874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(35%)Tj
1.9276 0 Td
(N)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 437.0456 345.5433 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 440.5606 347.1874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(and)Tj
1.7291 0 Td
(50%)Tj
1.9276 0 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 489.3165 345.5433 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 495.0425 347.1874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
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(\(purity)Tj
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0 Tc
2.999 0 Td
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/F5 1 Tf
-0.004 Tc
0.9921 0 Td
(99.999%;)Tj
-33.4939 -1.2982 Td
(Iwatani,)Tj
3.4526 0 Td
(Tokyo,)Tj
3.0217 0 Td
(Japan\).)Tj
3.0444 0 Td
(N)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 302.57 332.5606 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 306.1417 334.2047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-mixed)Tj
3.0727 0 Td
(gas)Tj
1.4797 0 Td
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1.7007 0 Td
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4.3087 0 Td
(of)Tj
1.0148 0 Td
(10%)Tj
1.9275 0 Td
(O)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 448.611 332.5606 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 452.1826 334.2047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(5%)Tj
1.4514 0 Td
(CO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 485.2913 332.5606 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.8062 334.2047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(and)Tj
1.7291 0 Td
(85%)Tj
1.9276 0 Td
(N)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 537.222 332.5606 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 540.7937 334.2047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(.)Tj
0.4422 0 Td
(Cells)Tj
-34.52 -1.2982 Td
(grown)Tj
2.7949 0 Td
(on)Tj
1.2756 0 Td
(culture)Tj
3.0387 0 Td
(dishes)Tj
2.6872 0 Td
(\(5)Tj
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1.0375 0 Td
[()]TJ
/F5 1 Tf
0.788 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 325.7574 325.644 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 329.3291 321.222 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/cm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 345.033 325.644 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 348.6047 321.222 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5555 0 Td
(for)Tj
1.389 0 Td
(1)Tj
0.6973 0 Td
(day)Tj
1.6328 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(5%)Tj
1.457 0 Td
(CO)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 436.8755 319.5212 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 442.6582 321.222 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(incubator)Tj
4.1045 0 Td
(were)Tj
2.1203 0 Td
(set)Tj
1.3039 0 Td
(in)Tj
1.0375 0 Td
(acrylamide)Tj
-32.8306 -1.3039 Td
(boxes)Tj
2.4832 0 Td
(\(6.8)Tj
/F15 1 Tf
1.7348 0 Td
[()]TJ
/F5 1 Tf
0.788 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 259.5968 312.6614 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 263.1685 308.1826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/cm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 278.8724 312.6614 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 282.444 308.1826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\),)Tj
0.788 0 Td
(which)Tj
2.6475 0 Td
(were)Tj
2.126 0 Td
(strewn)Tj
2.9026 0 Td
(with)Tj
2.0013 0 Td
(wet)Tj
1.6214 0 Td
(paper)Tj
2.4831 0 Td
(to)Tj
1.0262 0 Td
(prevent)Tj
3.2598 0 Td
(desiccation.)Tj
4.9266 0 Td
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1.7801 0 Td
(boxes)Tj
-33.8056 -1.2982 Td
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2.1203 0 Td
(sealed)Tj
2.6362 0 Td
(and)Tj
1.7291 0 Td
(filled)Tj
2.2222 0 Td
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(appropriate)Tj
4.8812 0 Td
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2.7213 0 Td
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1.4796 0 Td
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0.9525 0 Td
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0.6519 0 Td
(flow)Tj
1.9446 0 Td
(rate)Tj
1.7518 0 Td
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1.0148 0 Td
(1)Tj
0.6916 0 Td
(L/min)Tj
2.7269 0 Td
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1.3833 0 Td
(30)Tj
1.1736 0 Td
(min)Tj
1.8538 0 Td
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(normal)Tj
3.1464 0 Td
(pressure)Tj
3.5773 0 Td
(\()Tj
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(Fig)Tj
1.8197 0 Td
(1A)Tj
0 g
(\).)Tj
1.9446 0 Td
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2.2847 0 Td
(filling,)Tj
2.7723 0 Td
(cells)Tj
1.9218 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(boxes)Tj
2.4832 0 Td
(were)Tj
2.1203 0 Td
(incubated)Tj
4.1782 0 Td
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0.9525 0 Td
(37C)Tj
2.228 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(indi-)Tj
-34.7921 -1.3039 Td
(cated)Tj
2.3243 0 Td
(duration.)Tj
3.9288 0 Td
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5.2723 0 Td
(after)Tj
2.0353 0 Td
(incubation,)Tj
4.7735 0 Td
(the)Tj
1.474 0 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 405.7511 267.5338 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 411.5338 269.1779 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(O)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 436.2519 267.5338 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 442.0346 269.1779 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(concentrations)Tj
6.1794 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(culture)Tj
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(monitored)Tj
4.4901 0 Td
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1.9956 0 Td
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3.1918 0 Td
(electrodes)Tj
4.2292 0 Td
(\(Unisense,)Tj
4.4504 0 Td
(Aarhus)Tj
3.1293 0 Td
(N,)Tj
1.1792 0 Td
(Denmark\).)Tj
4.6148 0 Td
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2.829 0 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 566.022 254.5511 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 569.5937 256.1952 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-)Tj
-36.9578 -1.2982 Td
(mixed)Tj
2.7212 0 Td
(gas,)Tj
1.7065 0 Td
(the)Tj
1.4683 0 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 266.6834 241.5118 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 272.4094 243.2125 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(concentration)Tj
5.8223 0 Td
(was)Tj
1.6951 0 Td
(maintained)Tj
4.7905 0 Td
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0.9524 0 Td
(390)Tj
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[()]TJ
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(40)Tj
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3.1692 0 Td
[()]TJ
/F5 1 Tf
(M.)Tj
1.8425 0 Td
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2.8289 0 Td
(both)Tj
2.058 0 Td
(H)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 511.6535 241.5118 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 515.2251 243.2125 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-)Tj
0.5725 0 Td
(and)Tj
1.7292 0 Td
(N)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 545.6125 241.5118 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 549.1842 243.2125 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(-)Tj
-34.9169 -1.3039 Td
(mixed)Tj
2.7212 0 Td
(gases,)Tj
2.4889 0 Td
(the)Tj
1.474 0 Td
(O)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 274.2803 228.5291 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 280.0629 230.1732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(concentration)Tj
5.8166 0 Td
(was)Tj
1.7008 0 Td
(maintained)Tj
4.7905 0 Td
(at)Tj
0.9524 0 Td
(120)Tj
/F15 1 Tf
[()]TJ
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(10)Tj
/F15 1 Tf
3.1635 0 Td
[()]TJ
/F5 1 Tf
(M)Tj
1.6214 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1B)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 203.9811 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Cell)Tj
1.9134 0 Td
(survival)Tj
3.5622 0 Td
(assay)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 186.9732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Cells)Tj
2.1599 0 Td
(\(5)Tj
/F15 1 Tf
1.0375 0 Td
[()]TJ
/F5 1 Tf
0.788 0 Td
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 249.3921 191.4519 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 252.907 186.9732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/cm)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 268.6677 191.4519 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 272.1826 186.9732 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5612 0 Td
(grown)Tj
2.7949 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6577 0 Td
(24-)Tj
1.5193 0 Td
(or)Tj
1.0999 0 Td
(96-well)Tj
3.118 0 Td
(plate)Tj
2.143 0 Td
(for)Tj
1.3833 0 Td
(1)Tj
0.6973 0 Td
(day)Tj
1.6385 0 Td
(were)Tj
2.1203 0 Td
(used.)Tj
2.2847 0 Td
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1.627 0 Td
(pretreatment)Tj
5.4482 0 Td
(with)Tj
-35.3477 -1.2982 Td
(mixed)Tj
2.7212 0 Td
(gases,)Tj
2.4888 0 Td
(cells)Tj
1.9219 0 Td
(were)Tj
2.1202 0 Td
(incubated)Tj
4.1783 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(box)Tj
1.7008 0 Td
(containing)Tj
4.5297 0 Td
(an)Tj
1.2019 0 Td
(appropriate)Tj
4.8755 0 Td
(mixed)Tj
2.727 0 Td
(gas)Tj
1.4796 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(indi-)Tj
-34.486 -1.2983 Td
(cated)Tj
2.3244 0 Td
(duration.)Tj
3.9288 0 Td
(Immediately)Tj
5.2723 0 Td
(after)Tj
2.0352 0 Td
(exposure)Tj
3.8155 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.474 0 Td
(mixed)Tj
2.7212 0 Td
(gas,)Tj
1.7065 0 Td
(the)Tj
1.4683 0 Td
(culture)Tj
3.0387 0 Td
(medium)Tj
3.6057 0 Td
(was)Tj
1.7008 0 Td
(replaced)Tj
-34.1175 -1.2982 Td
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